The plan is to keep adding content like the new acts to the game instead of making sequels. Instead, Grinding Gear chose to add six new acts on top of the original four acts, more than doubling the size of the game.
With the Fall of Oriath expansion, the structure has shifted so that players no longer have to move through difficulty levels in order to reach higher difficulties. Originally, Path of Exile consisted of four Acts and multiple difficulty levels for each act – a game structure based on Diablo. The instanced areas are randomly generated, so levels are different every time you play. The actual multiplayer is online-only, but Grinding Gear tells us they'd like to add local multiplayer at some point in the future. Path of Exile's world includes shared encampments where players can meet and group up, as well as instanced areas to tackle solo or as part of a group.